Title: harmonic bundle and D-module Abstract: Recently, harmonic bundles with tame singularity have been studied, and we obtained a nice applicatoin to the theory of D-modules. It is attractive and challenging to obtain the generalization for harmonic bundles with non-tame singularity. It is expected to lead us deeper understanding of irregular singularities of flat connections and D-modules on higher dimensional varieties. After giving an overview of the study on tame harmonic bundles and the application to D-modules, we will explain what is known and what should be known for non-tame harmonic bundles.