Major revision, updated and expanded. About 180 new references. Improved introduction with added Section 1.2 on quadrupole formalism; More extensive description of asymptotic waveform and relation between radiative and source moments (Section 3.3); More complete discussion on radiation reaction effects (5.2) and explicit radiation reaction potentials (5.4); New Section 7.5 on the PN metric in the near zone; New sections on conservative dynamics: stability of orbits (8.2), first law of binary dynamics (8.3), comparison with self-force computations (8.4); New Section 9.5 on spherical-harmonic modes of gravitational waves; New sections on eccentric binaries: structure of the motion (10.1), quasi-Keplerian representation (10.2), averaged fluxes (10.3); New sections on spin effects: Lagrangian formalism (11.1), equations of motion (11.2), spin-orbit terms in the phase (11.3).